No Added Chemicals

In this section, we will see the synthesis of other types heteroaromatics which are indoles and 6-membered rings. Unsurprisingly, those classes of heteroaromatics are common in the organic compounds such as in pharmaceutical and in natural products.  This syntheses will be carried in the same principles as the 5-membered ring heteroaromatics, which is carbonyl chemistry.

Heteroaromatic compounds are commonly found in pharmaceutical, agrochemicals and many known chemicals in the world. In this section, we will see how heteroaromatic compounds can be synthesised and if we examine closely the key reactions in making heteroaromatic compounds are the carbonyls chemistry.

In this section, we will see the properties of heteroaromatic compounds especially their ability as nucleophile and as base. Besides that, we will also see the 5-membered heteroaromatic can also act as an acid. All those properties can be derived from its structure and the bonding.  Just to reiterate again for this section, the quoted value of p K a  in the discussion of basicity is the p K a  of its conjugate acid. 

A. Structure The structure of benzene was suggested firstly by Kekulé as a cyclic molecule but he also thought benzene had alternative single and double carbon-carbon bonds. The Kekulé structure is expected that benzene undergoes addition reaction. However, benzene is far less easily to undergo addition reaction than alkene, such as cyclohexene. Besides that, the carbon-carbon bond lengths of benzene are all identical, with the lengths intermediate between those single and double bonds.